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September 13, 1941


Author Affiliations

From the Division of Medicine of the Mayo Clinic.

JAMA. 1941;117(11):930-932. doi:10.1001/jama.1941.72820370004008

Pharmaceutic preparations of internal secretions of the pancreas are limited to insulin, modified insulins and lipocaic. Insulin is a secretory product of the beta cells of the islands of Langerhans; lipocaic may represent a secretion of the alpha cells of these islands. Evidence supporting this assumption has been presented by Dragstedt1 and by Bensley and Woerner.2

INSULIN  The principal use for insulin is in the control of diabetes. For this purpose it is indispensable. It has found employment also in the treatment of schizophrenia and in the management of malnutrition in certain cases. Claims have been made that the addition of insulin to the dextrose commonly given to patients with disease of the liver and to others following surgical operations is advantageous.

Preparations of Insulin.—  Insulin is a protein. Its molecular weight approximates that of egg albumin. It is made available commercially as a buffered solution of