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October 15, 1927


JAMA. 1927;89(16):1337-1338. doi:10.1001/jama.1927.02690160045017

Last October The Journal reviewed the status of fever-producing methods for the treatment of general paralysis.4 Since then much additional research has been reported, new facts have been discovered, and the actual status of various methods has been more firmly established. Driver, Gammel and Karnosh5 compiled a summary of the results in the 2,336 cases of general paralysis treated with malaria which had been recorded in the literature to April 1, 1926. The condition of 27.5 per cent of these patients was greatly improved; of 26.5 per cent, moderately improved, and of 46 per cent, unimproved or worse, or the patients were dead. The same authors applied malaria therapy to seventy-nine of their patients with syphilis of the central nervous system, most of whom, both before and after the malarial treatment, received other antisyphilitic therapy. In sixty-five of these patients it was possible to evaluate the effect of