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September 20, 1941

Le métabolisme de l'azoté: La physiologie des substances protéiques. II. Dégradation, synthèse, métabolisme intermédiaire

JAMA. 1941;117(12):1053-1054. doi:10.1001/jama.1941.02820380075033

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In this monograph the well known investigator aims to present a comprehensive, systematic and detailed summary of all the factors known about the degradation of endogenous and exogenous proteins or amino acid, of their intermediary metabolism, their synthesis in health and disease, and of the influence of the endocrine and nervous systems and various forms of therapy thereon. This is a tremendous undertaking because there is so much that is not known, especially about the endocrine and nervous system aspects, and yet much is implied if one searches the literature sufficiently. The author naturally makes much use of what he calls the "coefficient of protein oxidation" as a means of determining the extent of protein oxidation. The coefficient is applied to urine and is the quotient one obtains by dividing the total urea nitrogen by the sum of urea nitrogen, amino nitrogen and ammonia nitrogen found in urine. Uric acid,

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