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October 22, 1927


Author Affiliations

From the Cleveland Clinic.

JAMA. 1927;89(17):1380-1384. doi:10.1001/jama.1927.02690170004002

In the study of a large series of cases of diseases of the thyroid gland, one is impressed with the frequency with which disturbances of the heart are encountered, particularly in cases of hyperthyroidism. These cardiac disturbances vary from a simple tachycardia, or tachycardia associated with various forms of arrhythmia, to cardiac decompensation with engorged liver, ascites and edema of the feet. The important practical problems in these cases are the following: 1. Is the condition of the heart such that an operation for relief of the hyperthyroidism can be safely performed? 2. Will the condition of the heart be improved by such an operation?

The association of cardiac disturbances with goiter was recognized as early as 1815 by Parry, who in his original description cited the case of a patient whom he had seen in 1786. Graves (1835), Basedow (1845), Stokes (1854) and Trousseau (1856) also mention the cardiac