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October 22, 1927


JAMA. 1927;89(17):1390-1393. doi:10.1001/jama.1927.02690170014004

Angioneurotic edema is an extremely interesting problem—interesting not only because of the strange behavior of its manifestations but from the fact that its etiology remains inexplicable. Three forms of the condition have been recognized: (a) Charcot's edema; (b) Sydenham's edema, and (c) Quincke's circumscribed edema.

True circumscribed edema corresponds to the angioneurotic edema of Quincke, and it is this phase of the disorder that constitutes the subject of my thesis.

The disease has been known to the profession for almost 200 years, but not until 1882, when Quincke1 published his interpretation of the symptoms, did it attract general attention. Since then a considerable number of cases have been reported in the literature under such titles as acute circumscribed edema, wandering edema, giant urticaria, hydrops hypostrophos, noninflammatory edema and chronic neuropathic edema. Innumerable theories have also been advanced to account for this mysterious symptom complex, but so far our conception