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September 27, 1941


JAMA. 1941;117(13):1099-1100. doi:10.1001/jama.1941.02820390041014

Sognnaes,1 of the Department of Pathology, University of Rochester School of Medicine and Dentistry, reports that under certain favorable dietary conditions experimental dental caries in rats may be completely healed, with restoration of practically normal tooth structure. About ten years ago Hoppert and his co-workers,2 of the Department of Chemistry, Michigan State College, showed that dental caries can be regularly produced in rats by feeding certain coarse corn rations. The stock ration in the Michigan State laboratory consisted of finely ground (60 mesh) yellow corn (60 parts), whole milk powder (30 parts), linseed meal (6 parts), alfalfa meal (3 parts) and sodium chloride (1 part). Many years' experience has shown that this ration is fully adequate for optimal maintenance in rats and that with its use dental caries practically never develops. When coarse corn meal was substituted for the finely ground corn in this mixture, however, progressive dental