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October 22, 1927


JAMA. 1927;89(17):1439-1440. doi:10.1001/jama.1927.02690170063023

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Combined Serotherapy in Cholera Infantum  Dr. Lesage, physician to the Hôpital Pédiatrique Hérold, has been specializing for some time in the study of the micro-organisms that cause diarrheas in infants and young children. He has just made known a mode of treatment in summer diarrheas and cholera infantum which he has been experimenting with for the past thirty years. This disorder is due to a combination of three micro-organisms: B. oedematiens, B. perfringens and Vibrio septicus, all found in the soil. Dr. Lesage injects subcutaneously, at three different sites and at one sitting, 10 cc. of three serums prepared, respectively, from cultures of the three micro-organisms, and properly sterilized. He repeats the injections the day following and also the day thereafter, according to need. The results are more favorable the earlier the treatment is begun. The practical result of the inoculation of the three serums is that the loss of

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