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Article
October 4, 1941

MASSIVE DOSE ARSENOTHERAPY OF EARLY SYPHILIS BY INTRAVENOUS DRIP METHOD: RECAPITULATION OF THE DATA (1933 TO 1941)

Author Affiliations

NEW YORK
From the Department of Health of the City of New York (Dr. John L. Rice, Commissioner) and the First Medical Service of the Mount Sinai Hospital (Dr. George Baehr, Attending Physician).

JAMA. 1941;117(14):1154-1160. doi:10.1001/jama.1941.02820400012004
Abstract

Previous papers have dealt with the pharmacologic work underlying the adoption of the continuous intravenous drip method,1 the clinical results in earlier series,2 the organization of the supervisory committee,3 the technical considerations for the administration of the drug,4 the serologic5 and chemical studies,6 the organization of the follow-up clinic, under the direction of Dr. Evan Thomas7 and Dr. Bruce Webster,8 and the public health aspects.9

THE PLAN OF STUDY  Four groups of patients are included in the present summary (table 1).Group 1, studied in 1933, consisted of 25 patients2 who were given an average of 4 Gm. of neoarsphenamine over the course of five days.Group 2, studied in 1938, comprised 86 men10 treated in the same manner.Groups 1 and 2 constitute the neoarsphenamine series of 111 patients.Group 3, studied in 1938 and 1939, included 157

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