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October 4, 1941


JAMA. 1941;117(14):1185-1186. doi:10.1001/jama.1941.02820400043013

In recent years experimental investigations have demonstrated that the regulation of blood pressure is fundamentally an automatic, proprioceptive, reflex mechanism. The endovascular pressure itself regulates and automatically adapts the cardiac output, the circulating blood volume and the peripheral vascular resistance so well that the arterial pressure is maintained within normal limits. This automatic and proprioceptive regulation is effected mainly by the intermediation of the pressoreceptor innervation of different arterial and venous vascular areas. Knowledge of the role of the carotid sinus reflex in regulating and controlling the endovascular blood pressure is due chiefly to the researches of Hering.1 In 1923 he demonstrated that the same degree of slowing of the heart rate took place in animals when mechanical pressure was applied directly to the bifurcation of the common carotid artery even after the vagus was separated from the artery. Thus Czermak's explanation of the effect of pressure on the