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October 22, 1927

Glycogène, adrénaline et insuline.

JAMA. 1927;89(17):1448-1449. doi:10.1001/jama.1927.02690170072040

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This volume reports an extremely interesting investigation of some phases of carbohydrate metabolism. It represents a prodigious amount of work, and the experiments are carefully reported. The two most important conclusions which the author draws from his experimental results are that epinephrine causes the dissemination of glycogen (evidently glycogenolysis) by a physicochemical effect, which is indicated by an excessive brownian movement of granules of glycogen in the presence of epinephrine, and that glycogen accelerates the oxidation of epinephrine. The first conception is manifestly a theory and needs confirmation and investigation from various other angles. The second conception of the action of glycogen as an oxidizing agent is quite new, as is the author's deduction that dextrose also acts in this fashion. Further confirmation will certainly be needed before the idea can be accepted that a substance like dextrose, which in the past has been considered essentially a reducing agent, can

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