In the relatively short time since the announcement in 1938 of the synthesis of diethylstilbestrol by Dodds and his co-workers1 there have been a large number of reports of its use in clinical and experimental studies. An excellent review of the clinical literature has recently appeared.2 There seems to be general agreement among practically all clinical observers that diethylstilbestrol is a very potent estrogen, which is capable of reproducing all the known physiologic effects of the natural estrogens and of relieving symptoms in women suffering from estrogen deficiency. Nausea and occasional vomiting have occurred in a small percentage of patients treated by the majority of workers. A few observers3 have, however, reported a high incidence of untoward effects and have therefore questioned the advisability of its clinical use. A year ago we4 summarized our clinical and experimental studies at the end of one and one-half years'
MacBRYDE CM, CASTRODALE D, LOEFFEL E, FREEDMAN H. THE SYNTHETIC ESTROGEN DIETHYLSTILBESTROL: CLINICAL AND EXPERIMENTAL STUDIES (II). JAMA. 1941;117(15):1240–1242. doi:10.1001/jama.1941.02820410018005
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