This report is an analysis of the occurrence of herpes simplex1 as a complication of fever therapy. It is based on the records of 321 patients who were treated at the San Francisco Hospital and at the University of California Hospital.
Our purpose in this investigation is to determine whether the incidence of herpes is influenced by age, sex, disease or degree of the temperature induced during fever therapy, whether one attack of herpes protects against further attacks, what the relation is of individual susceptibility to the development of herpes and whether the incidence of herpes under these conditions is influenced by recent vaccination against smallpox.
REVIEW OF THE LITERATURE
Herpes is a common complication of pyrotherapy.2 In most patients the lesions appear twenty-four to thirty-six hours after the first treatment and heal in seven to ten days. The common sites are the lips, cheeks, eyelids and buccal
KEDDIE FM, REES RB, EPSTEIN NN. HERPES SIMPLEX FOLLOWING ARTIFICIAL FEVER THERAPY: SMALLPOX VACCINATION AS A FACTOR IN ITS PREVENTION. JAMA. 1941;117(16):1327–1330. doi:10.1001/jama.1941.02820420019006
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