Though kala-azar often devastates large territories in certain parts of the world in which it is constantly present, and though it has been subjected to numerous investigations, all attempts to transmit the disease to animals by natural means have been in vain. Only one really suitable experimental animal, a hamster, Cricetulus griseus, a variety of Chinese field mouse, has been found, and even this animal is said to contract kala-azar only when Leishman-Donovan bodies are injected directly into the peritoneal cavity or subcutaneous tissue, though many attempts have been made to transmit the disease from animal to animal by means of various biting insects.
In a series of recent experiments1 performed on this variety of hamster, we have brought forward what we think to be sound evidence showing that it is only within the cells of the reticuloendothelial system that the parasites of kala-azar are found, and that it
CASH JR, HU CH. KALA-AZAR: DEMONSTRATION OF LEISHMANIA DONOVANI IN THE SKIN AND SUBCUTANEOUS TISSUE OF PATIENTS: POSSIBLE RELATION TO THE TRANSMISSION OF THE DISEASE. JAMA. 1927;89(19):1576–1577. doi:10.1001/jama.1927.02690190014004
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