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October 18, 1941

Histopatología del cerebelo en la parálisis general progresiva: Formas cerebelosas de Alsheimer y desmielinizantes

JAMA. 1941;117(16):1401. doi:10.1001/jama.1941.02820420093046

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There have been few detailed studies of the histologic changes in the cerebellum as the result of dementia paralytica. The most marked signs of syphilis are not found in this organ but in the cerebral cortex, particularly in the frontotemporal lobes. The present monograph deals with the detailed examination of six brain specimens from cases of dementia paralytica with particular attention paid to the cerebellar findings. No previous publication has given such a detailed account of this particular part of the brain as affected by syphilis. In only one case study, moreover, was previous treatment with malaria used, so that we have reason to believe that the changes observed are actually the result of syphilis. There is nothing characteristic about these changes. The importance of Melgar's monograph lies in the fact that he has carefully studied the cerebellar tissue and has shown changes similar to those which occur in other

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