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To the Editor Dr Abegglen and colleagues1 confirmed a low cancer incidence in elephants and hypothesized that this relates to increased genomic protection by p53, possibly due to high copy numbers (20-40) of transcribed p53 pseudogenes. Also, peripheral lymphocytes and fibroblasts in elephants showed greater apoptotic sensitivity to ionizing radiation or doxorubicin than similar cells from humans.
Perez RP, Komiya T. TP53 Gene and Cancer Resistance in Elephants. JAMA. 2016;315(16):1789–1790. doi:10.1001/jama.2016.0446
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