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October 25, 1941


JAMA. 1941;117(17):1446-1447. doi:10.1001/jama.1941.02820430042012

Additional clinical evidence is now available concerning the prophylactic value of influenza vaccines. Two influenza A vaccines have been tested by Martin and Eaton1 of the State Department of Public Health, Berkeley, Calif.: (a) a living vaccine prepared by growing influenza A virus in minced chick embryo suspended in saline solution and (b) a complex nonviable vaccine prepared from chick embryos inoculated with both the PR 8 strain of influenza A virus and the virus of the X strain of canine distemper treated with formaldehyde and prepared according to the technic proposed by Horsfall, Lennette and Rickard.2 Both vaccines were given as a single subcutaneous dose, the inoculation occurring about two weeks before an outbreak of acute febrile respiratory disease clinically and serologically diagnosed as influenza A.

In one California institution 416 persons were vaccinated, and there were 4,560 nonvaccinated controls. At a second institution there were 413