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November 12, 1927


JAMA. 1927;89(20):1671-1672. doi:10.1001/jama.1927.02690200023007

This report relates to a type of splenomegaly found in two adult patients who presented a clinical and pathologic picture distinct from those previously noted, and constituting a separate disease entity.

CLINICAL FEATURES  The patients presented themselves complaining of abdominal tumor without other disability except general weakness and liability to fatigue. One was a woman, aged 34, the other a man, aged 43. There was no general adenopathy, and no icteric tint to the skin. The physical examination was entirely negative. Roentgen-ray studies made of the thoracic organs and gastro-intestinal tracts were without positive result. The urine was normal and in the second case did not show an excess of urobilinogen with Ehrlich's reagent. The first case was seen before this test came into use. The stools were normal microscopically and in the second case had no increase of urobilinogen. The blood observations were as follows; the limiting values found