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November 12, 1927


JAMA. 1927;89(20):1694. doi:10.1001/jama.1927.02690200046016

The formation and fate of the tubercles that are so characteristic of infection with tuberculosis play an important part in the resistance to the progress of the disease. The struggle between the tissues and the tubercle bacillus for mastery is essentially a local one. If the organism of the host is successful in effectually localizing the invaders, a victory over the disease is likely to be won. For this reason alone, if no other scientific interest were attached to it, the study of the organization and conquest of the tubercle is of great importance. The defense of the body against infection is not limited to a neutralization or detoxication of noxious products such as may occur when inorganic or organic poisons are introduced into the system. Cells and tissues may assume a more direct rôle in the protective reactions. Serum bacteriolysis and bacterial destruction by phagocytosis often give effective aid.