Previous studies on mice by one of us (M. L. C.)1 showed that one dose of 2 mg. of sulfathiazole or sulfapyridine administered by stomach tube three hours after the animals were infected with Shigella paradysenteriae (dysentery bacilli) resulted in survival of all mice inoculated with two minimum fatal doses, survival of the majority of mice inoculated with 100 minimum fatal doses and survival of a few mice inoculated with 1,000 minimum fatal doses.
Sulfathiazole was employed because our experience with the sulfonamide drugs indicated that sulfathiazole was tolerated better than sulfapyridine and also because our earlier experiments on mice showed that sulfathiazole and sulfapyridine were equally effective therapeutically. This study was started before sulfaguanidine became available, and the use of sulfathiazole was continued until a sufficient number of observations had been obtained from which conclusions could be drawn.
All patients were classified on admission into certain age groups:
COOPER ML, ZUCKER RL, WAGONER S, Brown EW, Bennett R. SULFATHIAZOLE FOR ACUTE DIARRHEA AND DYSENTERY OF INFANTS AND CHILDREN. JAMA. 1941;117(18):1520–1523. doi:10.1001/jama.1941.02820440028006
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