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Article
November 1, 1941

THE PRODUCTION OF EXPERIMENTAL OSTEOMYELITIS: PRELIMINARY REPORT

Author Affiliations

CHICAGO
From the Departments of Orthopedic Surgery, Bacteriology, Pathology and Roentgenology of Michael Reese Hospital.

JAMA. 1941;117(18):1525-1529. doi:10.1001/jama.1941.02820440033008
Abstract

We present herewith a preliminary report on our experimental production of a lesion simulating human osteomyelitis. We are able to keep the animals alive for an indefinite period.

For years attempts have been made to reproduce in animals lesions of bones resembling human osteomyelitis. These experimental efforts have taught us much about the pathogenesis of the disease. That osteomyelitis is an infectious disease was early recognized. Beginning with Rodet1 in 1884, Staphylococcus aureus was used to produce experimental lesions in bone. Rodet, and others shortly after him, produced abscesses in bones by injecting the organisms intravenously. Some years later Lexer2 studied osteomyelitis extensively from the anatomic and pathologic points of view. His description of the circulation in the long bones stands unaltered. He recognized early that osteomyelitis was a hematogenous infection. Lexer produced bone abscesses by the injection of small amounts of attenuated bacterial cultures intravenously and noted

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