Our purpose in this report is to record 2 cases of bulky plexiform neurofibroma involving the oral cavity and occurring as part of generalized neurofibromatous (von Recklinghausen's) disease. The neurofibromatous tumors which constitute the main characteristic of this disease occur most often in the subcutaneous tissues, and we have been unable to find any report in the literature of bulky intraoral involvement. Small isolated fibromas, probably representing the end stage in the organization of pyogenic granulomas, are common in the oral cavity, especially in the mucosa of the cheeks and the tip of the tongue, and should not be confused with these bulky lesions which have a different causation.
Of the 2 cases reported here, the intraoral growth in 1 has remained benign and is only slowly increasing in size. In the other case, the neurofibromatous invasion of the pharyngeal wall and the tongue was associated with a neurogenic sarcoma
Martin H, Graves CL. PLEXIFORM NEUROFIBROMA (VON RECKLINGHAUSEN'S DISEASE) INVADING THE ORAL CAVITY. JAMA. 1941;117(18):1535–1539. doi:10.1001/jama.1941.72820440003010b
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