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This review of the therapeutic value of malaria in general paralysis was written primarily for the physician and the medical student, with two main purposes in view: In part I the author sets forth the most recent information concerning clinical improvements and serologic modifications in the general paralytic patient following malarial therapy. This is preceded by a historical survey of our knowledge of the treatment of general paralysis and a review of the different fever-producing methods used in combating this disease. The author also discusses the theories advanced as to the manner by which malarial inoculation brings about the improvement. The fundamental factors concerned in these different theories are (1) leukocytosis; (2) psychologic; (3) high temperature; (4) metabolic; (5) antibody formation; (6) vasodilatation, and (7) the immunizing reaction against the stroma of destroyed red cells. In part II the author deals entirely with the new disease therapeutically induced to cure
Therapeutic Malaria. JAMA. 1927;89(20):1715. doi:10.1001/jama.1927.02690200067035
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