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Lab Reports
May 3, 2016

Diet-Induced Obesity and Diabetes Can Be Epigenetically Inherited

JAMA. 2016;315(17):1825. doi:10.1001/jama.2016.4948

Recent research has shown that the offspring of mice fed a high-fat diet are more susceptible to developing obesity and diabetes. Because of the study design, susceptibility in the offspring was not attributable to inheritable genetic variations. Rather, the results suggest that acquired metabolic disorders can be passed on epigenetically to offspring via oocytes and sperm.

For their experiments, investigators in Germany isolated gametes from parental mice that were exposed to a high-fat diet, low-fat diet, or normal standard chow for 6 weeks. All parental mice on the high-fat diet developed obesity and traits associated with type 2 diabetes. The researchers then implanted embryos derived from the isolated parental gametes via in vitro fertilization into healthy surrogate mothers. This allowed the team to exclude potential confounding variables, such as diet-induced environmental changes in utero, milk composition during lactation, and behavioral effects during postnatal care.