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November 1, 1941

Introduction to Physical Biochemistry

JAMA. 1941;117(18):1573. doi:10.1001/jama.1941.02820440081033

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The contents of the twelve chapters that make up this volume would have been better covered if "of the Blood" had been added to its title, for all but one of them are limited to a consideration of "the external environment of tissue cells." In toto, the book covers the application of standard physicochemical methods of analysis to the blood with the sixth chapter, however, thrown in on "characteristics of colloidal state of matter." Some historical asides here try to do justice to Thomas Graham's great discoveries and make fine reading; for the rest, however, the author believes that Graham's modern followers have added nothing that the physical chemists did not first bring in. The net result is that the blood remains an aqueous pabulum, still essentially a dilute solution, in spite of the author's warning that "a fluid such as blood cannot be considered as a simple solution"—in which

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