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Article
November 8, 1941

FURTHER EXPERIENCES WITH THIOCYANATES: CLINICAL AND EXPERIMENTAL OBSERVATIONS

Author Affiliations

CHICAGO
From the Department of Medicine, Northwestern University Medical School, and the Bettie Soper Clements Ward of Passavant Memorial Hospital.

JAMA. 1941;117(19):1591-1594. doi:10.1001/jama.1941.02820450015004
Abstract

Following our original report1 on the blood level control of administration of thiocyanate in the treatment of hypertension, there have been five2 publications and two reports3 which are in essential agreement with our original statements that blood pressure can be reduced and symptoms alleviated in more than 50 per cent of patients with hypertension provided that the criteria for adequate cyanate control are observed. The criteria of cyanate response used in our clinic are (1) general clinical improvement, (2) a substantial reduction in blood pressure (30 to 60 mm. systolic and 20 to 40 mm. diastolic) associated with (3) a blood cyanate concentration of from 8 to 12 mg. per hundred cubic centimeters.

The large number of questions that we have received from all parts of the country indicate that thiocyanate is being used extensively for the treatment of hypertension, and for this reason we feel that

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