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November 22, 1941


JAMA. 1941;117(21):1786-1787. doi:10.1001/jama.1941.02820470034012

Addis and his co-workers1 found that livers of albino rats lose, after a two day fast, 20 per cent of their original protein content, while the kidney, the heart and all other organs and tissues combined lose 4 per cent. The liver presumably is a depot for stored proteins, which may be used during fasting as glycogen is used during fasting. Goldschmidt, Vars and Ravdin2 demonstrated in rats that the incidence and the severity of damage to the hepatic cells twenty-four hours after one hour of chloroform anesthesia increases progressively with an increase in the concentration of lipids in the liver. A high protein diet previous to the anesthesia with chloroform reduced the incidence of hepatic cellular necrosis even in livers with a high lipid content and therefore in the face of a severe attack by chloroform. A high concentration of hepatic glycogen, per se, failed to confer