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November 22, 1941


JAMA. 1941;117(21):1806. doi:10.1001/jama.1941.02820470054024

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To the Editor:—  During the past six years each of us has administered a large number of doses of mercupurin to patients with congestive heart failure without any serious toxic reactions. Therefore we were startled on learning that we had independently within the last two months observed three deaths following an intravenous injection of the drug. On further inquiry we found that others of our acquaintance had recently observed extremely serious and even fatal reactions following promptly after the injection of mercupurin. Since the technic had been the same as that used by us in giving several thousand injections of mercupurin, we are at a loss for an adequate explanation of these recent reactions. Tyson (The Journal, September 20, p. 998) reported dangerous reactions after the injection of mercurials in cases of nephrosis; none of the fatal or nonfatal reactions noted by us occurred in patients with this malady.Since

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