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It has been the experience of every one who has employed the oral route in giving the dye for cholecystography to find undissolved capsules in the colon, when either the keratincoated or phenyl salicylate-coated preparation is used. To lessen the frequency with which this occurs, I have been using the plain gelatin capsule, uncoated. As the capsules are needed, they are filled with the dye.
The number of patients who have experienced symptoms of gastric irritation is no greater with the uncoated capsule than with the coated one. The results have been better, because nondigested capsules are rarely found, so that a maximum amount of dye is available for absorption. In this way, the information obtained from this procedure is perhaps more certain, and brings the oral route somewhat nearer to the perfection that has been achieved when the dye is injected intravenously.
Eight 5 grain capsules are used, as
Knapp V. A MODIFICATION IN THE ADMINISTRATION OF TETRAIODOPHENOLPHTHALEIN BY THE ORAL ROUTE FOR CHOLECYSTOGRAPHY. JAMA. 1927;89(23):1967. doi:10.1001/jama.1927.92690230002013b
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