A review of pneumonia in 731 children entering Cook County Hospital from April 1939 through May 1940 has enabled us to collect valuable data and make numerous observations on a disease which has recently held the limelight because of new trends in therapy. In view of the type of patients who frequent such a hospital (all are indigent and many are malnourished children in the late stages of the disease) this has been a severe test for the efficacy of drug therapy.
The original plan of the pneumonia service1 was to have a control series of patients receiving nonspecific therapy and a comparable group receiving specific serum or chemotherapy, but by the time sulfapyridine became available in sufficient quantities (April 1939) there had been satisfactory reports, experimental2 and clinical,3 to warrant the use of the drug. It was deemed unwise to withhold specific therapy from acutely ill
BUTLER CD, SHAW NG, HOFFMAN SJ, DITKOWSKY S, McVEY E, ZELDES M. PNEUMONIA IN CHILDREN: A REVIEW OF SEVEN HUNDRED AND THIRTYONE CASES. JAMA. 1941;117(22):1840–1843. doi:10.1001/jama.1941.02820480006002
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