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Article
December 3, 1927

PARIS

JAMA. 1927;89(23):1979. doi:10.1001/jama.1927.02690230063022

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Abstract

Fever Therapy in the Treatment of General Paralysis  Professor Sicard has recently induced high temperatures in patients with general paralysis by injecting intravenously a culture of Ducrey's bacillus, grown on gelose and sterilized, which he calls "dmelcos." It constitutes an effective vaccine in the treatment of simple or soft chancre. The injection is followed, one or two hours later, by a severe chill, and, during the hours following the chill, the temperature rises to 39.5, 40 and 40.5 C. The patient then develops a profuse sweat, and the temperature returns rapidly to normal. The first injection enables one to test the susceptibility of the subject, which will determine whether the dose to be employed is 1, 0.5 or 0.25 cc. Experience has shown that these injections, repeated every two days, until several dozen have been given, have never been followed by any untoward effect such as albuminuria or azotemia. The

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