Lymphogranuloma venereum is a systemic venereal disease caused by a filtrable virus and having an incubation period of from three to thirty days. It is characterized by a chronic granulomatous lesion which is generally confined to the anorectogenital region. Occasionally it is found in other parts of the body but rarely in the pharynx or larynx. Lymphogranuloma venereum must be differentiated from granuloma inguinale. The latter begins as an infection of the skin and subcutaneous tissues in which Donovan bodies can be demonstrated and is found almost exclusively in Negroes. On the other hand, lymphogranuloma venereum does not originate in the same structures and is not confined to Negroes.
Buboes of venereal nature were known centuries ago, but it was not until 1913 that Durand, Nicolas and Favre1 demonstrated that the disease causing them was transmitted through sexual intercourse. Hellerström2 stated that the description given by Greek, Roman
Myerson MC. LYMPHOGRANULOMA VENEREUM OF THE HYPOPHARYNX AND LARYNX. JAMA. 1941;117(22):1877–1879. doi:10.1001/jama.1941.72820480002011a
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