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Article
November 29, 1941

THE USE OF HISTAMINASE BY MOUTH IN PREVENTING SYSTEMIC REACTIONS TO PARENTERAL LIVER EXTRACT

Author Affiliations

Minneapolis
From the Division of Internal Medicine, University of Minnesota Hospital.

JAMA. 1941;117(22):1880-1881. doi:10.1001/jama.1941.72820480005011c
Abstract

The relative infrequency of severe reactions to liver extract is indicated by the fact that there are only 34 cases reported in the literature.1 The important data on these cases are shown in the accompanying table. In all but 2 instances the preparation was given parenterally. In many of the cases there was no previous history of abnormal sensitivity. That the sensitivity is acquired is indicated by the fact that in nearly every instance reactions occurred only after a number of injections had been given. The nature of the reactions varied from prolonged, generalized urticaria or pruritus to shocklike symptoms. It has been demonstrated (Criep1) that the sensitivity is to the liver as an organ and not to the general animal antigen. Passive transfer of sensitivity was accomplished in all cases in which it was attempted. One exception to these statements was the case of Milbradt's1 in

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