The relative infrequency of severe reactions to liver extract is indicated by the fact that there are only 34 cases reported in the literature.1 The important data on these cases are shown in the accompanying table. In all but 2 instances the preparation was given parenterally. In many of the cases there was no previous history of abnormal sensitivity. That the sensitivity is acquired is indicated by the fact that in nearly every instance reactions occurred only after a number of injections had been given. The nature of the reactions varied from prolonged, generalized urticaria or pruritus to shocklike symptoms. It has been demonstrated (Criep1) that the sensitivity is to the liver as an organ and not to the general animal antigen. Passive transfer of sensitivity was accomplished in all cases in which it was attempted. One exception to these statements was the case of Milbradt's1 in
Taylor CB, Hilger DW. THE USE OF HISTAMINASE BY MOUTH IN PREVENTING SYSTEMIC REACTIONS TO PARENTERAL LIVER EXTRACT. JAMA. 1941;117(22):1880–1881. doi:10.1001/jama.1941.72820480005011c
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: