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Article
November 29, 1941

ROENTGEN-RESISTANT VIRUS

JAMA. 1941;117(22):1892-1893. doi:10.1001/jama.1941.02820480058017
Abstract

The Shope papilloma virus is reported by Syverton1 and his colleagues of the departments of bacteriology and radiology, University of Rochester School of Medicine, to be resistant to many thousand times the roentgen therapeutic dose necessary for cure of the cutaneous lesion that the virus produces in rabbits. Hornlike protuberances on the inner surfaces of the thighs, the back of the neck or other parts of the body are fairly common in wild rabbits; an occasional cottontail has the whole body covered with such "warts." The individual "horns" often reach a centimeter or more in diameter, with a height of 1.5 to 2 cm. In 1933 Shope,2 of the Rockefeller Institute, reported that this cutaneous disease is readily transferred to wild rabbits by the application of glycerinated wart emulsions to slightly scarified cutaneous surfaces. The infective agent in such emulsions readily passes through the pores of a Berkefeld filter

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