It is established that long industrial exposure to cryolite1 or to crushed phosphate rock containing sodium fluoride as an impurity2 eventually causes severe generalized sclerosis of the skeleton, the tendinous attachments of muscles and of other body tissues. It is known also that the enamel of the permanent teeth of children will be mottled in a characteristic manner3 if the children habitually drink water containing 1 part or more per million of fluorine salts such as sodium fluoride during the years in which the enamel of these teeth is being laid down.4
Since mottled enamel is cosmetically undesirable, considerable effort has been exerted to avoid the use of contaminated water, but it has been assumed that the use of such water was not followed by deleterious lesions elsewhere in the body. Recently, however, there have been reported from North Africa,5 India6 and Argentina7
HODGES PC, FAREED OJ, RUGGY G, CHUDNOFF JS. SKELETAL SCLEROSIS IN CHRONIC SODIUM FLUORIDE POISONING. JAMA. 1941;117(23):1938. doi:10.1001/jama.1941.02820490012004
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