Try nonpharmacologic and nonopioid therapies first, the Centers for Disease Control and Prevention (CDC) recommended in a recently published opioid prescribing guideline for primary care clinicians in outpatient settings (Dowell D et al. JAMA. 2016;315[15]:1624-1645). The CDC’s call for nonpharmacologic approaches may serve to heighten clinician interest in nonpharmacologic strategies for managing chronic pain, such as mindfulness-based stress reduction (MBSR), commented Steven Stanos, DO, medical director for the Swedish Pain Services at Swedish Medical Center in Seattle, and president-elect of the American Academy of Pain Medicine.