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December 6, 1941

Studies in Haemolytic Streptococcus Fibrinolysin, Antifibrinolysin and Antistreptolysin, with Particular Reference to Rheumatic Fever

JAMA. 1941;117(23):2015. doi:10.1001/jama.1941.02820490089038

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This monograph contains a detailed and careful review of classification and antigenic properties of the streptococci, and numerous personal observations on fibrinolysis, antifibrinolysis and antistreptolysis. The work was carried out at the University of Lund, Sweden, from which other authors, connected with Dr. Winblad, have presented important contributions to the study of rheumatic fever. Therefore especial attention is directed to the significance of variations in titer of antifibrinolysin and antistreptolysin for the etiologic problem of rheumatic fever. In rheumatic fever the titer of both these antibodies rises to the level observed in other streptococcic diseases. The titer rises during the first weeks of the disease even if no accompanying or preceding streptococcic infection can be traced, and it slowly returns to normal, though it remains elevated longer than the sedimentation rate. In the interpretation of his data the author asks himself whether the occurrence of an elevated antibody titer against

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