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December 13, 1941

ACUTE HEMATOGENOUS STAPHYLOCOCCIC OSTEOMYELITISTREATMENT WITH SULFATHIAZOLE WITHOUT OPERATION

JAMA. 1941;117(24):2043-2050. doi:10.1001/jama.1941.02820500025005
Abstract

Sulfathiazole, with its bacteriostatic and bactericidal properties, offers a new approach to the treatment of acute staphylococcic osteomyelitis by attacking the staphylococcus organism both in the blood stream and in the local lesion.

Up to the advent of sulfathiazole the treatment of the bacteremia or the toxemia has been directed toward supportive methods, such as infusions, blood transfusions and the use of antitoxins, as advocated by Baker and Shands1 and other investigators. The universally accepted approach to the local lesion has been operative, varying from simple incision and drainage of the soft tissue abscess to more radical drilling or guttering of the bone. Authors are divided as to the extent and time of operation. One school, represented by such men as Hart,2 Fraser,3 Robertson4 and Conwell and Sherrill,5 advocates early incision of both bone and soft tissue. Another school advocates delayed operation and then only

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