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December 13, 1941

Die Störungen der Blutgerinnung beim Kinde mit besonderer Berücksichtigung des K-Vitamins und der Neugeborenenpathologie

JAMA. 1941;117(24):2107. doi:10.1001/jama.1941.02820500089036

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The recent discovery of vitamin K and the impetus it has given to a more intensive study of the problems of blood coagulation has resulted in the publication of concise monographs both in this country and abroad. This condensed presentation first reviews and summarizes the current views on blood coagulation and the methods available for the quantitative study of the various factors. The discussion of the five main factors concerned with disturbed blood coagulability is terse except for hypoprothrombinemia, which receives the major emphasis. The author attempts to evaluate the part that calcium, fibrinogen, thrombokinase (thromboplastin), heparin and prothrombin play in bleeding states in children. Fanconi frankly states that he has never seen a case of bleeding on the basis of insufficiency of fibrinogen and only 1 questionable case in which decrease in calcium may have been a factor. The role of insufficiency of thrombokinase (thromboplastin) is concerned mainly with

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