No group of therapeutic substances has gained such rapid and universal utilization as have the sulfonamides. It is undoubted that their advent has been the important therapeutic accession of the decade and that the control of many diseases caused by infectious agents now has been brought within the physician's grasp. It is equally true that there has developed a degree of uncertainty relative to the specific indications for the use of the sulfonamides, and in no part of the literature is this more evident than in the discussions of the treatment of gonococcic infection in the male.
Before the advent of the sulfonamides, how was gonorrhea cured? A host of chemicals and dyestuffs was given orally, first one and then another when the first seemed not to accomplish the desired result. A veritable flood of colored solutions was instilled onto the urethral mucosa or washed over its surface. Various vaccines
BROMME W. THE CHEMOTHERAPY OF GONORRHEAL URETHRITIS IN THE MALE. JAMA. 1941;117(25):2135–2139. doi:10.1001/jama.1941.02820510023006
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