The frequency with which an abnormal bacterial flora was found in cases of frank nasal infection and in the nasal passages of persons without objective changes in the nasal mucosa or subjective symptoms of sinus infection led us to undertake a systematic and comprehensive study of the bacteriology of the nose.
The nasal secretion of 500 consecutive patients admitted to our general medical service was cultured. The age of the patients varied from 4 weeks to 78 years. Cultures were made by inserting a sterile swab far back into the nasal cavity and streaking a blood (sheep blood) agar plate directly. Material from each side of the nose was cultured separately. In some cases cultures were made in the same manner with Löffler's medium. Cultures were made of sterilely obtained antral washings by inoculating nutrient broth, dextrose broth and blood agar plates. Cultures thus obtained were incubated at 37.5
JACOBSON LO, DICK GF. NORMAL AND ABNORMAL BACTERIAL FLORA OF THE NOSE. JAMA. 1941;117(26):2222–2225. doi:10.1001/jama.1941.02820520018004
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