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Article
December 27, 1941

THE FORMATION OF URINE

JAMA. 1941;117(26):2257-2258. doi:10.1001/jama.1941.02820520053016
Abstract

The early studies of Bowman, who maintained that the glomeruli of the kidney acted as filters and the cells of the tubules as secreting agents, together with the work of Heidenhain, who championed the conception that the formation of urine was entirely a secretory process, and the ideas of Ludwig, who thought that a process of absorption might occur in the tubules of the kidney, contribute interesting early chapters in the story of renal function. The more modern view so well expressed by Cushny,1 according to which the excretion of urine involves simple filtration in the glomeruli coupled with selective reabsorption in the tubules, is now familiar. The classic work of Wearn and Richards,2 who some two decades ago collected glomerular urine directly from Bowman's capsule in the living frog kidney by means of a capillary pipet, opened a new route of attack on the problem of glomerular

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