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December 27, 1941

Calculation of the Addis Count

JAMA. 1941;117(26):2265. doi:10.1001/jama.1941.02820520061023

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According to Dr. Ernest B. Zeisler of Chicago, the method of calculating the Addis count given in footnote 3 in the article by Pittinos, Craig and DeSanctis in The Journal, November 29, page 1855, contains an error. The first term in the numerator of the fraction reads "number of squares counted" instead of "number of casts or cells counted." The denominator reads "volume of area counted"; it is obvious that the authors mean "volume counted." Dr. Zeisler believes the formula could be amended as follows: Count the number of casts or cells, just as in a leukocyte count, in the four largest squares, namely 4 sq. mm., and call this n. Then the volume counted is 0.4 sq. mm. Now the formula for the total number of casts or cells per cubic centimeter in the twelve hour sample is or, briefly,

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