Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is an autosomal-dominant inherited cancer susceptibility syndrome that affects approximately 1 in 35 patients diagnosed with colorectal or endometrial cancers, making it the most common inherited cancer syndrome.1 Lifetime risk of colorectal cancer for men and women with Lynch syndrome is 10% to 80%, and women with Lynch syndrome have a 15% to 60% lifetime risk of developing endometrial cancer.
Pasche B, Pennison MJ, DeYoung B. Lynch Syndrome Testing: A Missed Opportunity in the Era of Precision Medicine. JAMA. 2016;316(1):38–39. doi:10.1001/jama.2016.8291
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