Elsewhere we1 have described the syndrome of "speed shock" resulting from the rapid intravenous injection of any molecule. The reaction which occurs within one minute of the introduction of the substance has for its major symptoms a rapid fall of blood pressure, respiratory irregularity and incoagulability of blood. At times death follows, but usually the animal makes a complete recovery.
The site of the disturbance that occurs in "speed shock" is probably the liver cell, and the pathogenesis appears to be similar to that found in anaphylactoid phenomena, the post-transfusion chill, the nitritoid crisis, protein shock and allied conditions, variously called colloidoclasis and hemoclasis. In our work we have shown the reaction to be independent of the "nature of the agent, its dose or concentration, or the functional state of the animal." We believe that "speed shock" is a reaction based on a technical error and not a physical,
HYMAN HT, HIRSHFELD S. STUDIES OF VELOCITY AND THE RESPONSE TO INTRAVENOUS INJECTIONSIII. TECHNIC OF THE INTRAVENOUS DRIP IN CLINICAL PRACTICE. JAMA. 1931;96(15):1221–1223. doi:10.1001/jama.1931.02720410031011
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