Workplace safety is a critical issue in health care. The National Institute for Occupational Safety and Health defines workplace violence as “violent acts (including physical assaults and threats of assaults) directed towards persons at work or on duty.”1 This Viewpoint discusses the scope and characteristics of workplace violence in health care settings, relevant government regulations, the responsibility of health care leaders in addressing workplace violence, a model program for violence prevention in health care settings, and a comprehensive environmental risk analysis.