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Comment & Response
July 26, 2016

Defining Septic Shock

Author Affiliations
  • 1Departamento de Mecicina Intensiva, Pontificia Universidad Católica de Chile, Santiago
  • 2Discipline of Anesthesiology, Pain, and Intensive Care, Federal University of São Paulo, São Paulo, Brazil
  • 3Intensive Care Medicine Department, Fundación Valle del Lili-Universidad ICESI, Cali, Colombia
JAMA. 2016;316(4):454-455. doi:10.1001/jama.2016.6137

To the Editor The proposed new definition of septic shock, part of the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), requires the simultaneous presence of hypotension and hyperlactatemia for making the diagnosis, instead of hypotension or hyperlactatemia.1 In our opinion, this is a step backward compared with previous definitions.