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Comment & Response
July 26, 2016

Definitions for Sepsis and Septic Shock

Author Affiliations
  • 1Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
JAMA. 2016;316(4):457. doi:10.1001/jama.2016.6380

To the Editor The new consensus definition for sepsis (Sepsis-3)1 relies on interpretation of a study on the performance of several scores in patients with suspected infection for mortality prediction.2 Although this is a commendable step forward compared with previous expert opinion-based criteria definitions,3 we fear unintended adverse effects. Unsurprisingly, as the SOFA score was developed for predicting mortality, it outperformed SIRS in the hospital setting.2 Based on this result, the authors abandoned SIRS from the sepsis definition, eliminated the first stage of the former sepsis-continuum4 (previously called sepsis), and reclassified it as infection.1