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Comment & Response
July 26, 2016

Clinical Criteria to Identify Patients With Sepsis

Author Affiliations
  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
JAMA. 2016;316(4):453. doi:10.1001/jama.2016.6407

To the Editor Dr Seymour and colleagues1 assessed the predictive validity of various clinical criteria to identify patients with sepsis. However, their conclusion that the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) scores are more clinically useful than the systemic inflammatory response syndrome (SIRS) criteria was primarily based on differences in the area under the receiver operating curve (AUROC), which has several limitations.2