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Clinical Trials Update
July 26, 2016

Whole-Body Hyperthermia Produces Antidepressant Effect

JAMA. 2016;316(4):385. doi:10.1001/jama.2016.9508

Heating the body to a state of mild hyperthermia created an antidepressant effect in people with major depressive disorder, according to a recent study (Janssen CW et al. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2016.1031 [published online May 12, 2016]). Raising participants’ core body temperature to 38.5°C significantly reduced depressive symptoms within 1 week of the intervention, and the effect was sustained for several weeks.