A new inhalation anesthetic agent is presented. To justify such a contribution, the drug must have advantages over the drugs in current use. We propose in this paper to present the results of a twelve months clinical study of cyclopropane, including over 2,000 clinical administrations, leaving the reader to judge whether the evidence warrants acceptance of this agent as an addition to the present therapeutic armamentarium.
John Snow was the first member of the medical profession to devote his attention to anesthesia. He was the first to appreciate the disadvantages as well as the advantages of ether as an anesthetic agent and he called attention to the unpleasant induction and recovery, difficulty of technic of administration and the irritation of the respiratory tract by that drug. He called attention to the safety of ether in comparison with chloroform through the improbability of causing primary cardiac damage by its use. Search
RALPH M. WATERS, ERWIN R. SCHMIDT. CYCLOPROPANE ANESTHESIA. JAMA. 1934;103(13):975–983. doi:10.1001/jama.1934.02750390019006